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Autonomic Dysfunction Predicts Poor Physical Improvement After Cardiac Rehabilitation in Patients With Heart Failure

Leonida Compostella 1 , * , Russo Nicola 1 , 2 , Setzu Tiziana 1 , Compostella Caterina 3 and Bellotto Fabio 1
Authors Information
1 Preventive Cardiology and Rehabilitation, Institute Codivilla-Putti, Cortina d'Ampezzo, Italy
2 Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua, Italy
3 Department of Medical and Surgical Sciences, School of Emergency Medicine, University of Padua, Padua, Italy
Article information
  • Research in Cardiovascular Medicine: November 30, 2014, 3 (4); e25237
  • Published Online: November 26, 2014
  • Article Type: Research Article
  • Received: November 9, 2014
  • Accepted: November 20, 2014
  • DOI: 10.5812/cardiovascmed.25237

To Cite: Compostella L, Nicola R, Tiziana S, Caterina C, Fabio B. et al. Autonomic Dysfunction Predicts Poor Physical Improvement After Cardiac Rehabilitation in Patients With Heart Failure, Res Cardiovasc Med. 2014 ;3(4):e25237. doi: 10.5812/cardiovascmed.25237.

Copyright: Copyright © 0, Research in Cardiovascular Medicine. .
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Triposkiadis F, Karayannis G, Giamouzis G, Skoularigis J, Louridas G, Butler J. The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications. J Am Coll Cardiol. 2009; 54(19): 1747-62[DOI][PubMed]
  • 2. Olshansky B, Sabbah HN, Hauptman PJ, Colucci WS. Parasympathetic nervous system and heart failure: pathophysiology and potential implications for therapy. Circulation. 2008; 118(8): 863-71[DOI][PubMed]
  • 3. Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Eur Heart J. 1996; 17(3): 354-81[PubMed]
  • 4. Lahiri MK, Kannankeril PJ, Goldberger JJ. Assessment of autonomic function in cardiovascular disease: physiological basis and prognostic implications. J Am Coll Cardiol. 2008; 51(18): 1725-33[DOI][PubMed]
  • 5. Nolan J, Batin PD, Andrews R, Lindsay SJ, Brooksby P, Mullen M, et al. Prospective study of heart rate variability and mortality in chronic heart failure: results of the United Kingdom heart failure evaluation and assessment of risk trial (UK-heart). Circulation. 1998; 98(15): 1510-6[PubMed]
  • 6. Bilchick KC, Fetics B, Djoukeng R, Fisher SG, Fletcher RD, Singh SN, et al. Prognostic value of heart rate variability in chronic congestive heart failure (Veterans Affairs' Survival Trial of Antiarrhythmic Therapy in Congestive Heart Failure). Am J Cardiol. 2002; 90(1): 24-8[PubMed]
  • 7. Rashba EJ, Estes NA, Wang P, Schaechter A, Howard A, Zareba W, et al. Preserved heart rate variability identifies low-risk patients with nonischemic dilated cardiomyopathy: results from the DEFINITE trial. Heart Rhythm. 2006; 3(3): 281-6[DOI][PubMed]
  • 8. Achten J, Jeukendrup AE. Heart rate monitoring: applications and limitations. Sports Med. 2003; 33(7): 517-38[PubMed]
  • 9. Kouidi E, Haritonidis K, Koutlianos N, Deligiannis A. Effects of athletic training on heart rate variability triangular index. Clin Physiol Funct Imaging. 2002; 22(4): 279-84[PubMed]
  • 10. Hottenrott K, Hoos O, Esperer HD. [Heart rate variability and physical exercise. Current status]. Herz. 2006; 31(6): 544-52[DOI][PubMed]
  • 11. Grant CC, Clark JR, Janse van Rensburg DC, Viljoen M. Relationship between exercise capacity and heart rate variability: supine and in response to an orthostatic stressor. Auton Neurosci. 2009; 151(2): 186-8[DOI][PubMed]
  • 12. Lee CM, Mendoza A. Dissociation of heart rate variability and heart rate recovery in well-trained athletes. Eur J Appl Physiol. 2012; 112(7): 2757-66[DOI][PubMed]
  • 13. Hedelin R, Bjerle P, Henriksson-Larsen K. Heart rate variability in athletes: relationship with central and peripheral performance. Med Sci Sports Exerc. 2001; 33(8): 1394-8[PubMed]
  • 14. Stanley J, D'Auria S, Buchheit M. Cardiac Parasympathetic Activity and Race Performance: An Elite Triathlete Case Study. Int J Sports Physiol Perform. 2014; [DOI][PubMed]
  • 15. ATS statement: guidelines for the six-minute walk test. Am J Respir Crit Care Med. 2002; 166(1): 111-7[DOI][PubMed]
  • 16. Balady GJ, Arena R, Sietsema K, Myers J, Coke L, Fletcher GF, et al. Clinician's Guide to cardiopulmonary exercise testing in adults: a scientific statement from the American Heart Association. Circulation. 2010; 122(2): 191-225[DOI][PubMed]
  • 17. de Sousa MR, Barbosa MP, Lombardi F, Ribeiro AL. Standard Deviation of normal interbeat intervals as a risk marker in patients with left ventricular systolic dysfunction: a meta-analysis. Int J Cardiol. 2010; 141(3): 313-6[DOI][PubMed]
  • 18. Yi G, Goldman JH, Keeling PJ, Reardon M, McKenna WJ, Malik M. Heart rate variability in idiopathic dilated cardiomyopathy: relation to disease severity and prognosis. Heart. 1997; 77(2): 108-14[PubMed]
  • 19. Fauchier L, Babuty D, Cosnay P, Autret ML, Fauchier JP. Heart rate variability in idiopathic dilated cardiomyopathy: characteristics and prognostic value. J Am Coll Cardiol. 1997; 30(4): 1009-14[PubMed]
  • 20. Hombach V. Electrocardiography of the failing heart. Cardiol Clin. 2006; 24(3): 413-26[DOI][PubMed]
  • 21. Passantino A, Lagioia R, Mastropasqua F, Scrutinio D. Short-term change in distance walked in 6 min is an indicator of outcome in patients with chronic heart failure in clinical practice. J Am Coll Cardiol. 2006; 48(1): 99-105[DOI][PubMed]
  • 22. Hautala AJ, Makikallio TH, Kiviniemi A, Laukkanen RT, Nissila S, Huikuri HV, et al. Cardiovascular autonomic function correlates with the response to aerobic training in healthy sedentary subjects. Am J Physiol Heart Circ Physiol. 2003; 285(4)-52[DOI][PubMed]
  • 23. Hautala AJ, Kiviniemi AM, Tulppo MP. Individual responses to aerobic exercise: the role of the autonomic nervous system. Neurosci Biobehav Rev. 2009; 33(2): 107-15[DOI][PubMed]
  • 24. Cahalin LP, Mathier MA, Semigran MJ, Dec GW, DiSalvo TG. The six-minute walk test predicts peak oxygen uptake and survival in patients with advanced heart failure. Chest. 1996; 110(2): 325-32[PubMed]
  • 25. Donal E, Coquerel N, Bodi S, Kervio G, Schnell F, Daubert JC, et al. Importance of ventricular longitudinal function in chronic heart failure. Eur J Echocardiogr. 2011; 12(8): 619-27[DOI][PubMed]
  • 26. Swedberg K, Komajda M. The beat goes on: on the importance of heart rate in chronic heart failure. Eur Heart J. 2012; 33(9): 1044-5[DOI][PubMed]
  • 27. Pepper GS, Lee RW. Sympathetic activation in heart failure and its treatment with beta-blockade. Arch Intern Med. 1999; 159(3): 225-34[PubMed]
  • 28. Binkley PF, Nunziata E, Haas GJ, Nelson SD, Cody RJ. Parasympathetic withdrawal is an integral component of autonomic imbalance in congestive heart failure: demonstration in human subjects and verification in a paced canine model of ventricular failure. J Am Coll Cardiol. 1991; 18(2): 464-72[PubMed]
  • 29. Algra A, Tijssen JG, Roelandt JR, Pool J, Lubsen J. Heart rate variability from 24-hour electrocardiography and the 2-year risk for sudden death. Circulation. 1993; 88(1): 180-5[PubMed]
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