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The Relation of Respiratory Muscle Strength to Disease Severity and Abnormal Ventilation During Exercise in Chronic Heart Failure Patients

Yusuke Kasahara 1 , * , Kazuhiro P. Izawa 2 , Satoshi Watanabe 3 , Naohiko Osada 4 and Kazuto Omiya 5
Authors Information
1 Department of Rehabilitation Medicine, St. Marianna University School of Medicine, Yokohama City Seibu Hospital, Yokohama, Japan
2 Graduate School of Health Sciences, Kobe University, Kobe, Japan
3 Department of Rehabilitation Medicine St. Marianna University School of Medicine Hospital, Kawasaki, Japan
4 Division of Cardiology, St. Marianna University School of Medicine Toyoko Hospital, Kawasaki, Japan
5 Division of Cardiology, Department of Internal Medicine (NO, KO), St. Marianna University School of Medicine, Yokohama City Seibu Hospital, Yokohama, Japan
Article information
  • Research in Cardiovascular Medicine: November 2015, 4 (4); e28944
  • Published Online: September 15, 2015
  • Article Type: Research Article
  • Received: April 1, 2015
  • Revised: May 8, 2015
  • Accepted: June 7, 2015
  • DOI: 10.5812/cardiovascmed.28944

To Cite: Kasahara Y, Izawa K P, Watanabe S, Osada N, Omiya K. et al. The Relation of Respiratory Muscle Strength to Disease Severity and Abnormal Ventilation During Exercise in Chronic Heart Failure Patients, Res Cardiovasc Med. 2015 ;4(4):e28944. doi: 10.5812/cardiovascmed.28944.

Copyright: Copyright © 2015, Research in Cardiovascular Medicine. .
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Drexler H, Riede U, Munzel T, Konig H, Funke E, Just H. Alterations of skeletal muscle in chronic heart failure. Circulation. 1992; 85(5): 1751-9[PubMed]
  • 2. Izawa KP, Watanabe S, Yokoyama H, Hiraki K, Morio Y, Oka K, et al. Muscle strength in relation to disease severity in patients with congestive heart failure. Am J Phys Med Rehabil. 2007; 86(11): 893-900[DOI][PubMed]
  • 3. Pina IL. Exercise and Heart Failure: A Statement From the American Heart Association Committee on Exercise, Rehabilitation, and Prevention. Circulation. 2003; 107(8): 1210-25[DOI]
  • 4. McParland C, Krishnan B, Wang Y, Gallagher CG. Inspiratory muscle weakness and dyspnea in chronic heart failure. Am Rev Respir Dis. 1992; 146(2): 467-72[DOI][PubMed]
  • 5. Yokoyama H, Sato H, Hori M, Takeda H, Kamada T. A characteristic change in ventilation mode during exertional dyspnea in patients with chronic heart failure. Chest. 1994; 106(4): 1007-13[PubMed]
  • 6. Witte KK, Thackray SD, Nikitin NP, Cleland JG, Clark AL. Pattern of ventilation during exercise in chronic heart failure. Heart. 2003; 89(6): 610-4[PubMed]
  • 7. Metra M, Cas LD, Panina G, Visioli O. Exercise hyperventilation chronic congestive heart failure, and its relation to functional capacity and hemodynamics. Am J Cardiol. 1992; 70(6): 622-8[DOI]
  • 8. Ponikowski PP, Chua TP, Francis DP, Capucci A, Coats AJ, Piepoli MF. Muscle ergoreceptor overactivity reflects deterioration in clinical status and cardiorespiratory reflex control in chronic heart failure. Circulation. 2001; 104(19): 2324-30[PubMed]
  • 9. Agostoni P, Pellegrino R, Conca C, Rodarte JR, Brusasco V. Exercise hyperpnea in chronic heart failure: relationships to lung stiffness and expiratory flow limitation. J Appl Physiol (1985). 2002; 92(4): 1409-16[DOI][PubMed]
  • 10. Piepoli MF, Dimopoulos K, Concu A, Crisafulli A. Cardiovascular and ventilatory control during exercise in chronic heart failure: role of muscle reflexes. Int J Cardiol. 2008; 130(1): 3-10[DOI][PubMed]
  • 11. Meyer FJ, Zugck C, Haass M, Otterspoor L, Strasser RH, Kubler W, et al. Inefficient ventilation and reduced respiratory muscle capacity in congestive heart failure. Basic Res Cardiol. 2000; 95(4): 333-42[PubMed]
  • 12. Habedank D, Reindl I, Vietzke G, Bauer U, Sperfeld A, Glaser S, et al. Ventilatory efficiency and exercise tolerance in 101 healthy volunteers. Eur J Appl Physiol Occup Physiol. 1998; 77(5): 421-6[DOI][PubMed]
  • 13. Trojnarska O, Gwizdala A, Katarzynski S, Katarzynska A, Szyszka A, Lanocha M, et al. Evaluation of exercise capacity with cardiopulmonary exercise test and B-type natriuretic peptide in adults with congenital heart disease. Cardiol J. 2009; 16(2): 133-41[PubMed]
  • 14. Beaver WL, Wasserman K, Whipp BJ. A new method for detecting anaerobic threshold by gas exchange. J Appl Physiol (1985). 1986; 60(6): 2020-7[PubMed]
  • 15. Arena R, Humphrey R, Peberdy MA. Prognostic ability of VE/VCO2 slope calculations using different exercise test time intervals in subjects with heart failure. Eur J Cardiovasc Prev Rehabil. 2003; 10(6): 463-8[DOI][PubMed]
  • 16. Akaishi S, Adachi H, Oshima S, Taniguchi K, Hasegawa A, Kurabayashi M. Relationship between exercise tolerance and TV vs. RR relationship in patients with heart disease. J Cardiol. 2008; 52(3): 195-201[DOI][PubMed]
  • 17. Borg G. Subjective effort and physical activities. Scand J Rehab. 1978; 6: 108-13
  • 18. Black LF, Hyatt RE. Maximal respiratory pressures: normal values and relationship to age and sex. Am Rev Respir Dis. 1969; 99(5): 696-702[PubMed]
  • 19. Meyer FJ, Borst MM, Zugck C, Kirschke A, Schellberg D, Kubler W, et al. Respiratory muscle dysfunction in congestive heart failure: clinical correlation and prognostic significance. Circulation. 2001; 103(17): 2153-8[PubMed]
  • 20. Mancini DM, Henson D, LaManca J, Levine S. Respiratory muscle function and dyspnea in patients with chronic congestive heart failure. Circulation. 1992; 86(3): 909-18[PubMed]
  • 21. Stanek B, Frey B, Hülsmann M, Berger R, Sturm B, Strametz-Juranek J, et al. Prognostic evaluation of neurohumoral plasma levels before and during beta-blocker therapy in advanced left ventricular dysfunction. J American College Cardiol. 2001; 38(2): 436-42[DOI]
  • 22. Maisel AS, Kazanegra R, McCullough PA, McCord J, Nowak RM, Hollander JE, et al. Beside B-type natriuretic peptide in the emergency diagnosis of systolic and nonsystolic heart failure: Results from the breathing not properly (BNP) multinational study. J Am College Cardiol. 2003; 41(6): 143[DOI]
  • 23. Larsen AI, Skadberg O, Aarsland T, Kvaloy JT, Lindal S, Omland T, et al. B-type natriuretic peptide is related to histological skeletal muscle abnormalities in patients with chronic heart failure. Int J Cardiol. 2009; 136(3): 358-62[DOI][PubMed]
  • 24. Lindsay DC, Lovegrove CA, Dunn MJ, Bennett JG, Pepper JR, Yacoub MH, et al. Histological abnormalities of muscle from limb, thorax and diaphragm in chronic heart failure. Eur Heart J. 1996; 17(8): 1239-50[PubMed]
  • 25. Howell S, Maarek JM, Fournier M, Sullivan K, Zhan WZ, Sieck GC. Congestive heart failure: differential adaptation of the diaphragm and latissimus dorsi. J Appl Physiol (1985). 1995; 79(2): 389-97[PubMed]
  • 26. Ambrosino N, Opasich C, Crotti P, Cobelli F, Tavazzi L, Rampulla C. Breathing pattern, ventilatory drive and respiratory muscle strength in patients with chronic heart failure. Eur Respir J. 1994; 7(1): 17-22[PubMed]
  • 27. Witte KK, Nikitin NP, De Silva R, Cleland JG, Clark AL. Exercise capacity and cardiac function assessed by tissue Doppler imaging in chronic heart failure. Heart. 2004; 90(10): 1144-50[DOI][PubMed]
  • 28. Woods PR, Olson TP, Frantz RP, Johnson BD. Causes of breathing inefficiency during exercise in heart failure. J Card Fail. 2010; 16(10): 835-42[DOI][PubMed]
  • 29. Chua TP, Clark AL, Amadi AA, Coats AJ. Relation between chemosensitivity and the ventilatory response to exercise in chronic heart failure. J Am Coll Cardiol. 1996; 27(3): 650-7[PubMed]
  • 30. Dall'Ago P, Chiappa GR, Guths H, Stein R, Ribeiro JP. Inspiratory muscle training in patients with heart failure and inspiratory muscle weakness: a randomized trial. J Am Coll Cardiol. 2006; 47(4): 757-63[DOI][PubMed]
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