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Effect of Dexmedetomidine Infusion on Hemodynamics and Stress Responses in Pediatric Cardiac Surgery: A Randomized Trial

Ziae Totonchi 1 , Hengameh Rezvani 2 , Masoud Ghorbanloo 3 , Forouzan Yazdanian 1 , Mohammad Mahdavi 1 , Nima Babaali 1 , Shirin Salajegheh 4 and Mitra Chitsazan 1 , *
Authors Information
1 Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IR Iran
2 Iran University of Medical Sciences, Tehran, IR Iran
3 Hasheminejad Kidney Center, Iran University of Medical Sciences, Tehran, IR Iran
4 Kerman University of Medical Sciences, Kerman, IR Iran
Article information
  • Research in Cardiovascular Medicine: January 2017, 6 (1); e35016
  • Published Online: July 2, 2016
  • Article Type: Research Article
  • Received: November 26, 2015
  • Revised: December 16, 2015
  • Accepted: December 21, 2015
  • DOI: 10.5812/cardiovascmed.35016

To Cite: Totonchi Z, Rezvani H, Ghorbanloo M, Yazdanian F, Mahdavi M, et al. Effect of Dexmedetomidine Infusion on Hemodynamics and Stress Responses in Pediatric Cardiac Surgery: A Randomized Trial, Res Cardiovasc Med. 2017 ;6(1):e35016. doi: 10.5812/cardiovascmed.35016.

Abstract
Copyright: Copyright © 2017, Research in Cardiovascular Medicine. .
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
Footnote
References
  • 1. Naito Y, Tamai S, Shingu K, Shindo K, Matsui T, Segawa H, et al. Responses of plasma adrenocorticotropic hormone, cortisol, and cytokines during and after upper abdominal surgery. Anesthesiology. 1992; 77(3): 426-31[PubMed]
  • 2. Tsukada K, Katoh H, Shiojima M, Suzuki T, Takenoshita S, Nagamachi Y. Concentrations of cytokines in peritoneal fluid after abdominal surgery. Eur J Surg. 1993; 159(9): 475-9[PubMed]
  • 3. Homburger JA, Meiler SE. Anesthesia drugs, immunity, and long-term outcome. Curr Opin Anaesthesiol. 2006; 19(4): 423-8[DOI][PubMed]
  • 4. Kurosawa S, Kato M. Anesthetics, immune cells, and immune responses. J Anesth. 2008; 22(3): 263-77[DOI][PubMed]
  • 5. Kennedy BC, Hall GM. Neuroendocrine and inflammatory aspects of surgery: do they affect outcome? Acta Anaesthesiol Belg. 1999; 50(4): 205-9[PubMed]
  • 6. Westaby S, Saatvedt K, White S, Katsumata T, van Oeveren W, Halligan PW. Is there a relationship between cognitive dysfunction and systemic inflammatory response after cardiopulmonary bypass? Ann Thorac Surg. 2001; 71(2): 667-72[PubMed]
  • 7. Desborough JP. The stress response to trauma and surgery. Br J Anaesth. 2000; 85(1): 109-17[PubMed]
  • 8. Savola JM, Virtanen R. Central alpha 2-adrenoceptors are highly stereoselective for dexmedetomidine, the dextro enantiomer of medetomidine. Eur J Pharmacol. 1991; 195(2): 193-9[PubMed]
  • 9. Virtanen R, Savola JM, Saano V, Nyman L. Characterization of the selectivity, specificity and potency of medetomidine as an alpha 2-adrenoceptor agonist. Eur J Pharmacol. 1988; 150(1-2): 9-14[PubMed]
  • 10. Venn RM, Bradshaw CJ, Spencer R, Brealey D, Caudwell E, Naughton C, et al. Preliminary UK experience of dexmedetomidine, a novel agent for postoperative sedation in the intensive care unit. Anaesthesia. 1999; 54(12): 1136-42[PubMed]
  • 11. Triltsch AE, Welte M, von Homeyer P, Grosse J, Genahr A, Moshirzadeh M, et al. Bispectral index-guided sedation with dexmedetomidine in intensive care: a prospective, randomized, double blind, placebo-controlled phase II study. Crit Care Med. 2002; 30(5): 1007-14[PubMed]
  • 12. Venn M, Newman J, Grounds M. A phase II study to evaluate the efficacy of dexmedetomidine for sedation in the medical intensive care unit. Intensive Care Med. 2003; 29(2): 201-7[DOI][PubMed]
  • 13. Khan ZP, Ferguson CN, Jones RM. alpha-2 and imidazoline receptor agonists. Their pharmacology and therapeutic role. Anaesthesia. 1999; 54(2): 146-65[PubMed]
  • 14. Ebert TJ, Hall JE, Barney JA, Uhrich TD, Colinco MD. The effects of increasing plasma concentrations of dexmedetomidine in humans. Anesthesiology. 2000; 93(2): 382-94[PubMed]
  • 15. Kunisawa T, Nagata O, Iwasaki H. [Pharmacokinetic simulation of high-dose administration of dexmedetomidine for decubitus treatment]. Masui. 2006; 55(8): 995-8[PubMed]
  • 16. Maze M, Scarfini C, Cavaliere F. New agents for sedation in the intensive care unit. Crit Care Clin. 2001; 17(4): 881-97[PubMed]
  • 17. Herr DL, Sum-Ping ST, England M. ICU sedation after coronary artery bypass graft surgery: dexmedetomidine-based versus propofol-based sedation regimens. J Cardiothorac Vasc Anesth. 2003; 17(5): 576-84[PubMed]
  • 18. Mangano DT. Perioperative cardiac morbidity. Can J Anaesthes. 1994; 41(1)-9
  • 19. Goldfarb Y, Sorski L, Benish M, Levi B, Melamed R, Ben-Eliyahu S. Improving postoperative immune status and resistance to cancer metastasis: a combined perioperative approach of immunostimulation and prevention of excessive surgical stress responses. Ann Surg. 2011; 253(4): 798-810[DOI][PubMed]
  • 20. Tasdogan M, Memis D, Sut N, Yuksel M. Results of a pilot study on the effects of propofol and dexmedetomidine on inflammatory responses and intraabdominal pressure in severe sepsis. J Clin Anesth. 2009; 21(6): 394-400[DOI][PubMed]
  • 21. Wu CT, Jao SW, Borel CO, Yeh CC, Li CY, Lu CH, et al. The effect of epidural clonidine on perioperative cytokine response, postoperative pain, and bowel function in patients undergoing colorectal surgery. Anesth Analg. 2004; 99(2): 502-9[DOI][PubMed]
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